Hayley L Letson Selected Research

Lidocaine (Xylocaine)

1/2022	ALM Fluid Therapy Shifts Sympathetic Hyperactivity to Parasympathetic Dominance in the Rat Model of Non-Compressible Hemorrhagic Shock.
12/2021	Comparison of intra-articular administration of adenosine, lidocaine and magnesium solution and tranexamic acid for alleviating postoperative inflammation and joint fibrosis in an experimental model of knee arthroplasty.
1/2021	Buprenorphine Analgesia Reduces Survival With ALM Resuscitation in a Rat Model of Uncontrolled Hemorrhage: Concerns for Trauma-Related Research.
1/2021	The Role of Nitric Oxide in the Efficacy of Adenosine, Lidocaine, and Magnesium Treatment for Experimental Hemorrhagic Shock in Rats.
1/2020	Adenosine, Lidocaine, and Magnesium Support a High Flow, Hypotensive, Vasodilatory State With Improved Oxygen Delivery and Cerebral Protection in a Pig Model of Noncompressible Hemorrhage.
1/2020	Living in a Hostile World: Inflammation, New Drug Development, and Coronavirus.
4/2019	Absence of cytotoxic and inflammatory effects following in vitro exposure of chondrogenically-differentiated human mesenchymal stem cells to adenosine, lidocaine and Mg2+ solution.
1/2018	Adenosine, lidocaine, and Mg2+ (ALM) resuscitation fluid protects against experimental traumatic brain injury.
1/2017	3% NaCl adenosine, lidocaine, Mg2+ (ALM) bolus and 4 hours "drip" infusion reduces noncompressible hemorrhage by 60% in a rat model.
4/2015	Correction of acute traumatic coagulopathy with small-volume 7.5% NaCl adenosine, lidocaine, and Mg2+ occurs within 5 minutes: a ROTEM analysis.

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Hayley L Letson Research Topics

Disease

12	Inflammation (Inflammations) 01/2022 - 08/2015
12	Hemorrhagic Shock 01/2022 - 06/2011
11	Hemorrhage 01/2022 - 08/2015
11	Wounds and Injuries (Trauma) 01/2022 - 09/2014
6	Shock 01/2022 - 08/2012
2	Burns 01/2021 - 01/2019
2	Tics (Tic) 03/2020 - 08/2015
2	Heart Failure 01/2020 - 01/2017
2	Multiple Organ Failure (MODS) 01/2020 - 01/2019
2	Sepsis (Septicemia) 01/2020 - 09/2014
2	Infections 09/2019 - 01/2019
2	Heart Arrest (Cardiac Arrest) 12/2014 - 09/2013
1	Anterior Cruciate Ligament Injuries 10/2022
1	Ischemia 01/2022
1	Margins of Excision 01/2022
1	Necrosis 01/2022
1	Fibrosis (Cirrhosis) 12/2021
1	Pica (Geophagia) 01/2021
1	Hyperthermia 01/2021
1	Cicatrix (Scar) 01/2021
1	Acute Lung Injury 01/2021
1	Weight Loss (Weight Reduction) 01/2021
1	Hypoxia (Hypoxemia) 01/2020
1	COVID-19 01/2020
1	Endotoxemia 01/2020
1	Compartment Syndromes 01/2019
1	Traumatic Brain Injuries (Traumatic Brain Injury) 01/2018
1	Brain Injuries (Brain Injury) 01/2018
1	Postpartum Hemorrhage 01/2018
1	Hypertension (High Blood Pressure) 01/2017
1	Postoperative Pain 01/2017
1	Respiratory Alkalosis 01/2017
1	Thrombocytopenia (Thrombopenia) 01/2017
1	Coronary Artery Disease (Coronary Atherosclerosis) 01/2017
1	Obesity 01/2017
1	Acidosis 05/2016
1	Thrombosis (Thrombus) 08/2015
1	Confusion (Bewilderment) 08/2015
1	Hypotension (Low Blood Pressure) 12/2014
1	Edema (Dropsy) 09/2014

Drug/Important Bio-Agent (IBA)

17	Adenosine (Adenocard)FDA LinkGeneric 01/2022 - 09/2011
16	Lidocaine (Xylocaine)FDA LinkGeneric 01/2022 - 09/2011
7	MagnesiumIBA 01/2022 - 09/2011
5	Fibrinogen (Factor I)FDA Link 03/2020 - 05/2016
4	Tranexamic Acid (AMCA)FDA Link 12/2021 - 01/2017
4	Lactic Acid (Lactate)FDA LinkGeneric 01/2020 - 05/2016
3	Buprenorphine (Subutex)FDA LinkGeneric 01/2022 - 01/2017
3	SolutionsIBA 12/2021 - 04/2019
3	adenocaineIBA 09/2013 - 12/2011
2	Adrenergic Agents (Adrenergic Drugs)IBA 01/2022 - 11/2021
2	CytokinesIBA 01/2021 - 01/2018
2	Analgesics (Analgesic Drugs)IBA 01/2021 - 01/2017
2	Thrombin FDA Link 03/2020 - 08/2015
2	salicylhydroxamic acid (SHAM)IBA 01/2019 - 04/2015
1	Cholinergic ReceptorsIBA 01/2022
1	Cholinergic Agents (Cholinergics)IBA 01/2022
1	Muscarinic Receptors (Muscarinic Acetylcholine Receptor)IBA 11/2021
1	Sodium Chloride FDA LinkGeneric 01/2021
1	Nitric Oxide (Nitrogen Monoxide)FDA Link 01/2021
1	Matrix Metalloproteinases (MMPs)IBA 01/2021
1	Matrix Metalloproteinase 9 (Gelatinase B)IBA 01/2021
1	carprofen FDA Link 01/2021
1	Tissue Inhibitor of Metalloproteinase-1IBA 01/2021
1	Biomarkers (Surrogate Marker)IBA 01/2021
1	ThrombomodulinIBA 03/2020
1	AnnexinsIBA 03/2020
1	Glycerol (Glycerine)FDA LinkGeneric 01/2020
1	Pharmaceutical PreparationsIBA 01/2020
1	Oxygen (Dioxygen)IBA 01/2020
1	AntigensIBA 01/2020
1	Biocompatible Materials (Biomaterials)IBA 09/2019
1	Vancomycin FDA LinkGeneric 01/2019
1	Anti-Bacterial Agents (Antibiotics)IBA 01/2019
1	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 01/2018
1	Chemokine CCL5IBA 01/2018
1	Protamines (Protamine Sulfate)FDA Link 01/2017
1	Saline SolutionIBA 01/2017
1	antineoplaston A10 (A 10)IBA 05/2016
1	Plasminogen Activator Inhibitor 1IBA 05/2016
1	P-SelectinIBA 05/2016
1	FibrinIBA 08/2015
1	Dacarbazine (DIC)FDA LinkGeneric 08/2015

Therapy/Procedure

10	Resuscitation 01/2021 - 09/2011
9	Therapeutics 01/2022 - 09/2014
6	Drug Therapy (Chemotherapy) 10/2022 - 09/2013
3	Fluid Therapy (Oral Rehydration Therapy) 01/2022 - 01/2020
3	Laparotomy 11/2021 - 01/2017
2	Analgesia 01/2022 - 01/2021
2	Knee Replacement Arthroplasty (Total Knee Replacement) 12/2021 - 09/2019
2	Intravenous Infusions 01/2018 - 01/2017
1	Catheters 01/2021
1	Continuity of Patient Care 01/2020
1	Defibrillators (Defibrillator) 01/2020
1	Reoperation 09/2019
1	Anesthesia 01/2019
1	Phage Therapy 01/2019
1	Orthopedic Procedures 06/2018
1	Sternotomy 01/2017
1	Ligation 09/2014
1	Punctures 09/2014